{"id":159,"date":"2021-08-29T12:20:21","date_gmt":"2021-08-29T12:20:21","guid":{"rendered":"https:\/\/caagw.org\/cn\/?p=159"},"modified":"2021-08-29T12:23:40","modified_gmt":"2021-08-29T12:23:40","slug":"%e5%8d%83%e4%ba%ba%e4%ba%91%e8%81%9a%e5%a4%a7%e4%b8%93%e8%81%94%e7%a7%91%e6%8a%80%e8%ae%b2%e5%ba%a7-%e7%83%ad%e8%ae%ae%e6%96%b0%e5%86%a0%e7%96%ab%e8%8b%97%e7%a0%94%e5%8f%91%e4%b8%8e%e6%8e%a5","status":"publish","type":"post","link":"https:\/\/caagw.org\/cn\/%e5%8d%83%e4%ba%ba%e4%ba%91%e8%81%9a%e5%a4%a7%e4%b8%93%e8%81%94%e7%a7%91%e6%8a%80%e8%ae%b2%e5%ba%a7-%e7%83%ad%e8%ae%ae%e6%96%b0%e5%86%a0%e7%96%ab%e8%8b%97%e7%a0%94%e5%8f%91%e4%b8%8e%e6%8e%a5\/","title":{"rendered":"\u5343\u4eba\u4e91\u805a\u5927\u4e13\u8054\u79d1\u6280\u8bb2\u5ea7 &#8211; \u70ed\u8bae\u65b0\u51a0\u75ab\u82d7\u7814\u53d1\u4e0e\u63a5\u79cd"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"352\" src=\"https:\/\/i0.wp.com\/caagw.org\/cn\/wp-content\/uploads\/2021\/08\/caagw_2.8_1.png?resize=640%2C352&#038;ssl=1\" alt=\"\" class=\"wp-image-160\" srcset=\"https:\/\/i0.wp.com\/caagw.org\/cn\/wp-content\/uploads\/2021\/08\/caagw_2.8_1.png?w=651&amp;ssl=1 651w, https:\/\/i0.wp.com\/caagw.org\/cn\/wp-content\/uploads\/2021\/08\/caagw_2.8_1.png?resize=300%2C165&amp;ssl=1 300w, https:\/\/i0.wp.com\/caagw.org\/cn\/wp-content\/uploads\/2021\/08\/caagw_2.8_1.png?resize=549%2C302&amp;ssl=1 549w, https:\/\/i0.wp.com\/caagw.org\/cn\/wp-content\/uploads\/2021\/08\/caagw_2.8_1.png?resize=470%2C258&amp;ssl=1 470w, https:\/\/i0.wp.com\/caagw.org\/cn\/wp-content\/uploads\/2021\/08\/caagw_2.8_1.png?resize=233%2C128&amp;ssl=1 233w, https:\/\/i0.wp.com\/caagw.org\/cn\/wp-content\/uploads\/2021\/08\/caagw_2.8_1.png?resize=230%2C126&amp;ssl=1 230w, https:\/\/i0.wp.com\/caagw.org\/cn\/wp-content\/uploads\/2021\/08\/caagw_2.8_1.png?resize=360%2C198&amp;ssl=1 360w, https:\/\/i0.wp.com\/caagw.org\/cn\/wp-content\/uploads\/2021\/08\/caagw_2.8_1.png?resize=100%2C55&amp;ssl=1 100w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><figcaption>\u7740\u65b0\u51a0mRNA\u75ab\u82d7\u5728\u5168\u7f8e\u8303\u56f4\u5f00\u59cb\u5e7f\u6cdb\u63a5\u79cd\uff0c\u4eba\u4eec\u5bf9\u8fd9\u79cd\u4e0d\u5230\u4e00\u5e74\u5c31\u9762\u4e16\u7684\u65b0\u51a0\u75ab\u82d7\u65e2\u597d\u5947\u53c8\u5145\u6ee1\u4e86\u6797\u6797\u603b\u603b\u7684\u7591\u95ee\u4e0e\u56f0\u60d1\uff0c\u56e0\u4e3a\u8fc7\u53bb\u6210\u529f\u7814\u53d1\u4e00\u4e2a\u75ab\u82d7\u5e73\u5747\u9700\u898110\u523015\u5e74\u7684\u65f6\u95f4\u3002\u4e3a\u4e86\u89e3\u9664\u4eba\u4eec\u5fc3\u4e2d\u7684\u7591\u60d1\uff0c\u7f8e\u4e1c\u65f6\u95f42021\u5e741\u670830\u65e5\u665a8\u70b9\uff0c\u7f8e\u56fd\u5927\u534e\u5e9c\u5730\u533a\u4e2d\u56fd\u5927\u4e13\u9662\u6821\u6821\u53cb\u4f1a\u8054\u5408\u4f1a (\u5927\u4e13\u8054\uff0cCAAGW) \u548c\u4e2d\u79d1\u9662\u4e0a\u6d77\u751f\u5316\u7ec6\u80de\u7814\u7a76\u6240\u6d77\u5916\u8054\u8c0a\u4f1a (SICBC-OA) \u9762\u5411\u5927\u534e\u5e9c\u534e\u4eba\u793e\u533a\uff0c\u4e3e\u529e\u4e86\u9898\u4e3a \u201cFeatured Seminar and Discussion on COVID-19 Vaccines\u201d\u7684\u4e91\u7aef\u8bb2\u5ea7\u66a8\u8ba8\u8bba\u4f1a\u3002\u8bb2\u5ea7\u7684\u79d1\u5b66\u6027\u3001\u4e13\u4e1a\u6027\u548c\u6743\u5a01\u6027\u5438\u5f15\u4e86\u8bb8\u591a\u89c2\u4f17\uff0c\u4e0d\u4f46\u53ef\u4ee5\u5bb9\u7eb3500\u4eba\u7684ZOOM\u5728\u8bb2\u5ea7\u8fc7\u7a0b\u4e2d\u6301\u7eed\u7206\u6ee1\uff0c\u800c\u4e14\u4e0d\u65ad\u6709\u8bf7\u6c42\u52a0\u5165\u8005\uff0c\u8fdeYouTube\u73b0\u573a\u76f4\u64ad\u4e5f\u805a\u96c6\u4e86\u4e0a\u5343\u4eba\u5728\u7ebf\u8046\u542c\u3002<br>\u5927\u4e13\u8054\u7b2c\u4e00\u671f\u79d1\u6280\u4e91\u7aef\u8bb2\u5ea7\u66a8\u8ba8\u8bba\u4f1a\u7531\u526f\u4f1a\u957f\u97e9\u519b\u4e3b\u6301\u3002\u8bb2\u5ea7\u7279\u9080\u65b0\u51a0\u75ab\u82d7\u7814\u53d1\u524d\u6cbf\u9886\u5934\u79d1\u5b66\u5bb6Kizzmekia S. Corbett\u535a\u58eb\u4e3a\u4e3b\u8bb2\u5609\u5bbe\uff0c\u6821\u53cb\u5218\u7fe0\u5e73\u535a\u58eb\u4e3a\u4e3b\u6301\u4eba\uff0c\u6f14\u8bb2\u4e3b\u9898\u4e3a\u201cRapid SARS-CoV-2 Vaccine Development (\u65b0\u51a0\u75ab\u82d7\u7684\u5feb\u901f\u7814\u53d1)\u201d\u3002\u4f5c\u4e3a\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662 (NIH) \u7f8e\u56fd\u56fd\u7acb\u8fc7\u654f\u4e0e\u4f20\u67d3\u75c5\u7814\u7a76\u6240 (NIAID) \u75ab\u82d7\u7814\u7a76\u4e2d\u5fc3 (VRC) \u526f\u603b\u76d1Barney Graham\u535a\u58eb\u56e2\u961f\u4e2d\u7684\u8d44\u6df1\u7814\u7a76\u5b66\u8005(Senior Research Fellow)\uff0c\u4e3b\u8bb2\u5609\u5bbeCorbett\u535a\u58eb\u9886\u5bfcVRC\u51a0\u72b6\u75c5\u6bd2\u7814\u7a76\u56e2\u961f\uff0c\u4e0e\u7f8e\u56fd\u83ab\u5fb7\u7eb3\u516c\u53f8\uff08Moderna, Inc\uff09\u5408\u4f5c\uff0c11\u4e2a\u6708\u5185\u7814\u53d1\u4e86mRNA-1273\u65b0\u51a0\u75ab\u82d7\u3002\u76ee\u524d\u8fd9\u6b3e\u75ab\u82d7\u5df2\u7ecf\u83b7\u5f97FDA\u7d27\u6025\u4f7f\u7528\u6388\u6743\uff0c\u5e76\u5728\u5168\u7f8e\u5927\u8303\u56f4\u63a5\u79cd\u3002<br><img data-recalc-dims=\"1\" decoding=\"async\"   src=\"https:\/\/i0.wp.com\/caagw.org\/sites\/default\/files\/images\/caagw_2.8_2.png?w=640&#038;ssl=1\"><br>\u572845\u5206\u949f\u98ce\u8da3\u6d3b\u6cfc\u7684\u6f14\u8bb2\u4e2d\uff0cCorbett\u535a\u58eb\u8be6\u7ec6\u8bb2\u8ff0\u4e86mRNA-1273\u75ab\u82d7\u7684\u7814\u53d1\u80cc\u666f\u4ee5\u53ca\u5979\u7684\u56e2\u961f\u4e0e\u65f6\u95f4\u8d5b\u8dd1\u3001\u4e0eSARS-CoV-2\u75c5\u6bd2\u8d5b\u8dd1\u7684\u7cbe\u5f69\u5386\u7a0b\u3002<br>Corbett\u535a\u58eb\u6307\u51fa\uff0c mRNA-1273\u75ab\u82d7\u7684\u5feb\u901f\u7814\u53d1\u6210\u529f\u5e76\u975e\u4e00\u8e74\u800c\u5c31\uff0c\u800c\u662f\u57fa\u4e8e\u79d1\u5b66\u5bb6\u4eec2013\u5e74\u52302019\u5e74\u95f4\u5bf9\u4eba\u7c7b\u51a0\u72b6\u75c5\u6bd2HKU1\u3001\u4e25\u91cd\u6025\u6027\u547c\u5438\u9053\u7efc\u5408\u5f81\u75c5\u6bd2 (SARS)\u548c\u4e2d\u4e1c\u547c\u5438\u7efc\u5408\u5f81\u75c5\u6bd2 (MERS) \u7b49\u4e59\u578b\u51a0\u72b6\u75c5\u6bd2\u7814\u7a76\u5de5\u4f5c\u7684\u5927\u91cf\u79ef\u7d2f\u3002\u65e9\u671f\u5bf9\u8fd9\u4e9b\u4e59\u578b\u51a0\u72b6\u75c5\u6bd2\u7684\u7ed3\u6784\u7814\u7a76\u63ed\u793a\u4e86\u8fd9\u4e9b\u75c5\u6bd2\u68d8\u7a81\u86cb\u767d\u80de\u5916\u7ed3\u6784\u57df\u7684\u7ed3\u6784\u548c\u611f\u67d3\u673a\u5236\uff1b\u540c\u65f6\u8fd8\u53d1\u73b0\uff0c\u53ef\u4ee5\u901a\u8fc7\u5728HR1\u6a21\u4f53 (motif) \u4e4b\u540e\u5f15\u5165\u4e24\u4e2a\u812f\u6c28\u9178 (proline) \u7a81\u53d8\uff0c\u628a\u591a\u79cd\u4e59\u578b\u51a0\u72b6\u75c5\u6bd2\u68d8\u7a81\u86cb\u767d\u7a33\u5b9a\u5728\u878d\u5408\u524d\u6784\u8c61 (\u4ee5\u4e0b\u7b80\u79f0\u68d8\u7a81\u86cb\u767d\u7684\u4e24\u4e2a\u812f\u6c28\u9178\u7a81\u53d8\u4f53\u4e3aS-2P)\u3002\u6b64\u5916\uff0cCorbett\u535a\u58eb\u6240\u9886\u5bfc\u7684\u56e2\u961f\u4e0eRalph S. Baric\u535a\u58eb\u56e2\u961f\u5408\u4f5c\u53d1\u73b0\uff0c MERS\u75c5\u6bd2S-2P\u7a81\u53d8\u4f53\u7684mRNA\u5728\u5c0f\u9f20\u4e2d\u514d\u75ab\u539f\u6027\u6bd4S-2P\u86cb\u767d\u9ad810\u500d\uff0c\u53ef\u4ee5\u6709\u6548\u4fdd\u62a4\u5c0f\u9f20\u514d\u4e8eMERS\u75c5\u6bd2\u7684\u611f\u67d3\u3002<br>2020\u5e741\u670810\u65e5\uff0c\u4e2d\u56fd\u79d1\u5b66\u5bb6\u516c\u5e03SARS-CoV-2\u57fa\u56e0\u7ec4\u5e8f\u5217\uff0c\u63ed\u793aSARS-CoV-2\u5c5e\u4e8e\u4e59\u578b\u51a0\u72b6\u75c5\u6bd2\uff0c\u5176\u68d8\u7a81\u86cb\u767d\u4e0e\u5176\u5b83\u4e59\u578b\u51a0\u72b6\u75c5\u6bd2\u7684\u68d8\u7a81\u86cb\u767d\u5177\u6709\u9ad8\u5ea6\u540c\u6e90\u6027\u3002\u57fa\u4e8e\u4e0a\u8ff0\u4fe1\u606f\uff0cCorbett\u535a\u58eb\u7684\u7814\u7a76\u56e2\u961f\u51b3\u5b9a\u4e0e\u83ab\u5fb7\u7eb3\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0Moderna\uff09\u5408\u4f5c\uff0c\u9009\u7528mRNA\u5e73\u53f0\uff0c \u5171\u540c\u7814\u53d1\u65b0\u51a0\u75ab\u82d7\uff0c\u56e0\u4e3amRNA\u5e73\u53f0\u5177\u6709\u5feb\u901f\u3001\u53ef\u9760\u53ca\u901a\u7528\u7684\u7279\u70b9\uff0c\u975e\u5e38\u9002\u5408\u65b0\u51a0\u8fd9\u7c7b\u5927\u6d41\u884c\u75c5\u75ab\u82d7\u7814\u53d1\u7684\u8feb\u5207\u9700\u8981\uff1b \u5e76\u4e14\uff0cModerna\u5df2\u7ecf\u62e5\u6709\u591a\u9879mRNA\u5e73\u53f0\u548c\u4f20\u9012\u6280\u672f\u4e13\u5229\uff0c\u5177\u5907\u5feb\u901f\u751f\u4ea7GMP\u7ea7\u522bmRNA\u4ea7\u54c1\u7684\u80fd\u529b\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u7814\u53d1\u56e2\u961f\u4e0eJason McLellan\u535a\u58eb\u8bfe\u9898\u7ec4\u8bbe\u8ba1\u4e86SARS-CoV-2\u68d8\u7a81\u86cb\u767d\u878d\u5408\u524d\u6784\u8c61\u7684\u7a81\u53d8\u4f53 (SARS-CoV-2 S-2P)\uff0c\u5e76\u5f00\u59cb\u8fdb\u884c\u7ed3\u6784\u7814\u7a76\u3002VRC\u56e2\u961f\u7740\u624b\u5c0f\u9f20\u8bd5\u9a8c\u4ee5\u53caIND \u63d0\u4ea4\u4e4b\u524d\u7684\u51c6\u5907\u5de5\u4f5c\u3002\u81f3\u6b64\uff0c\u53d1\u4ee4\u67aa\u54cd\uff0cCorbett\u535a\u58eb\u9886\u5bfc\u7684\u65b0\u51a0\u75ab\u82d7\u7814\u53d1\u56e2\u961f\u5175\u5206\u591a\u8def\uff0c\u5f00\u59cb\u65e5\u4ee5\u7ee7\u591c\u5730\u4e0e\u65f6\u95f4\u8d5b\u8dd1\uff0c\u4e0e\u65b0\u51a0\u75c5\u6bd2\u8d5b\u8dd1\u3002<br>3\u5929\u540e (2020\u5e741\u670813\u65e5) \uff0c\u56e2\u961f\u4e0eModerna\u786e\u5b9a\u65b0\u51a0mRNA\u75ab\u82d7\u7684\u5e8f\u5217\uff0c\u5e76\u547d\u540d\u4ea7\u54c1\u4e3amRNA-1273\u3002<br>4\u5929\u540e (2020\u5e741\u670814\u65e5) \uff0cModerna\u5f00\u59cb\u751f\u4ea7GMP\u7ea7\u522b\u7684mRNA-1273\u4ea7\u54c1\u3002<br>23\u5929\u540e (2020\u5e742\u67082\u65e5) \uff0cModerna\u9a8c\u8bc1mRNA-1273\u7684\u4f53\u5916\u8868\u8fbe\u3002<br>25\u5929\u540e (2020\u5e742\u67084\u65e5) \uff0cVRC \u5f00\u59cb\u5c0f\u9f20\u8bd5\u9a8c\uff0cModerna\u5bc4\u51fa\u4e34\u5e8a\u524dmRNA-1273\u4ea7\u54c1\u3002<br>40\u5929\u540e (2020\u5e742\u670819\u65e5) \uff0c\u56e2\u961f\u83b7\u5f97\u5c0f\u9f20\u514d\u75ab\u539f\u6027\u7ed3\u679c\uff0c\u5e76\u548cJason McLellan\u535a\u58eb\u56e2\u961f\u53d1\u8868SARS-CoV-2 S-2P \u7684\u51b7\u51bb\u7535\u955c\u7ed3\u6784\u3002<br>41\u5929\u540e (2020\u5e742\u670820\u65e5) \uff0c\u56e2\u961f\u5411FDA\u63d0\u4ea4IND\u7533\u8bf7\u3002<br>45\u5929\u540e (2020\u5e742\u670824\u65e5) \uff0cModerna\u5bc4\u51fa\u4e34\u5e8a\u8bd5\u9a8c\u7528mRNA-1273\u3002<br>52\u5929\u540e (2020\u5e743\u67082\u65e5) \uff0cFDA \u6279\u51c6IND\u7533\u8bf7<br>66 \u5929\u540e (2020\u5e743\u670816\u65e5) \uff0cI\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5f00\u59cb<br>140\u5929\u540e (2020\u5e745\u670829\u65e5) \uff0cII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5f00\u59cb<br>Corbett\u535a\u58eb\u5728\u8bb2\u5ea7\u4e2d\u5c55\u793a\uff1a\u5728\u7334\u5b50\u8bd5\u9a8c\u4e2d\uff0c100\u5fae\u514b \uff08\u4ee5\u4e0b\u7b80\u79f0 \u00b5g\uff09 mRNA-1273\u75ab\u82d7\u53ef\u4ee5\u6fc0\u53d1\u4ea7\u751f\u6bd4\u65b0\u51a0\u60a3\u8005\u75c5\u6108\u540e\u81ea\u8eab\u4ea7\u751f\u7684\u6297\u4f53\u6ef4\u5ea6\u66f4\u9ad8\u7684\u6297\u4f53\uff0c\u6709\u6548\u9632\u6b62\u7334\u5b50\u547c\u5438\u9053\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u3002I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u663e\u793a\uff1a56\u5c81\u4ee5\u4e0a\u4eba\u7fa4\uff0c\u5305\u62ec71\u5c81\u4ee5\u4e0a\u7684\u8001\u4eba\uff0c100 \u00b5g mRNA-1273\u6ce8\u5c04\u4e24\u6b21\u53ef\u4ee5\u4ea7\u751f1000\u500d\u4ee5\u4e0a\u4e2d\u548c\u6297\u4f53\u6ef4\u5ea6\u3002 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data-recalc-dims=\"1\" decoding=\"async\"   src=\"https:\/\/i0.wp.com\/caagw.org\/sites\/default\/files\/images\/caagw_2.8_3.png?w=640&#038;ssl=1\"><br>\u4e3b\u6301\u4eba\uff1amRNA\u5e73\u53f0\u5728\u8fd9\u6b21\u5168\u7403\u65b0\u51a0\u75ab\u82d7\u7ade\u8d5b\u4e2d\u660e\u663e\u80dc\u51fa\u3002\u4f46\u662f\u5728\u75ab\u82d7\u7814\u53d1\u521d\u671f\uff0cmRNA\u5e73\u53f0\u5e76\u6ca1\u6709\u5728\u4eba\u4f53\u5927\u89c4\u6a21\u5e94\u7528\u3002Barney Graham\u535a\u58eb\u53ca\u56e2\u961f\u9009\u62e9mRNA\u5e73\u53f0\u65f6\u6709\u6ca1\u6709\u62c5\u5fc3mRNA\u5e73\u53f0\u7684\u98ce\u9669\uff1f\u6709\u5176\u5b83\u5907\u7528\u7b56\u7565\u5417\uff1f<br>Corbett\uff1amRNA\u5e73\u53f0\u7684\u786e\u6ca1\u6709\u5927\u89c4\u6a21\u7528\u4e8e\u4eba\u4f53\u3002\u4f46\u662f\uff0cmRNA\u5df2\u7ecf\u7528\u4e8e\u51e0\u5343\u4eba\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002Zika mRNA\u75ab\u82d7\u4e34\u5e8a\u8bd5\u9a8c\u73b0\u6b63\u5728\u5df4\u897f\u8fdb\u884c\uff0c\u8fd8\u6709CMV (Cytomegalovirus) mRNA\u75ab\u82d7\u3002Moderna\u516c\u53f8\u4e8b\u5b9e\u4e0a\u662f\u4ee5\u764c\u75c7\u7597\u6cd5\u8d77\u5bb6\u7684\uff0c\u4ed6\u4eec\u53ef\u4ee5\u5b9a\u5411\u4f20\u9012\u9776\u6807mRNA\u836f\u7269\u5230\u7624\u4f53\u3002\u8fd9\u4e9b\u6280\u672f\u975e\u5e38\u6709\u5e0c\u671b\uff0c\u800c\u4e14\u662f\u7ecf\u5386\u4e86\u4e34\u5e8a\u8bd5\u9a8c\u7684\u3002\u6211\u4eec\u77e5\u9053\u4ed6\u4eec\u7684\u5e73\u53f0\u5f88\u5b89\u5168\uff0c\u56e0\u4e3a\u4f7f\u7528\u4e86\u4ed6\u4eec\u8fd9\u79cd\u7597\u6cd5\u7684\u4eba\u4eec\u5df2\u7ecf\u88ab\u8ffd\u8e2a\u4e86\u597d\u51e0\u5e74\uff0c\u800c\u4e14\u4ed6\u4eec\u53ef\u4ee5\u5feb\u901f\u5730\u751f\u4ea7\u8fd9\u7c7b\u5b89\u5168\u7684\u3001GMP\u7ea7\u522b\u7684mRNA\u4ea7\u54c1\u3002\u8fd9\u4e8b\u5b9e\u4e0a\u662f\u4ed6\u4eec\u600e\u6837\u4ece\u7845\u8c37\u62ff\u5230\u8d44\u52a9\u7684\uff0c\u56e0\u4e3a\u4ed6\u4eec\u5c55\u793a\u4ed6\u4eec\u53ef\u4ee5\u5f88\u5feb\u5730\u4eceA\u5230Z (\u7b14\u8005\u6ce8\uff1a\u751f\u4ea7mRNA\u4ea7\u54c1)\u3002\u6240\u4ee5\uff0cmRNA\u5e73\u53f0\u662f\u663e\u800c\u6613\u89c1\u7684\u9009\u62e9\uff0c\u5c24\u5176\u662f\u6839\u636e\u6211\u4eec\u4ee5\u524d\u89c1\u5230\u7684\u6570\u636e\u3002\u5728Zika\u671f\u95f4\uff0c\u4ed6\u4eec\u8bd5\u4e86VRC\u7684DNA \u5e73\u53f0\uff0c\u540c\u6837\u7684\u86cb\u767d\u5229\u7528Moderna\u7684mRNA\u5e73\u53f0\uff0cmRNA\u7684\u514d\u75ab\u539f\u6027\u662fVRC\u7684DNA \u5e73\u53f0\u7684\u5341\u500d\u3002\u5f88\u660e\u663e\uff0cmRNA\u5e73\u53f0\u4e0d\u4ec5\u5b89\u5168\u5feb\u901f\uff0c\u800c\u4e14\u53ef\u4ee5\u7ed9\u4f60\u683c\u5916\u5f3a\u7684\u514d\u75ab\u53cd\u5e94\u3002\u8fd9\u53ef\u80fd\u662f\u4e3a\u4ec0\u4e48\u6211\u4eec\u7684\u75ab\u82d7\u4e0e\u5176\u4ed6\u75ab\u82d7\u76f8\u6bd4\uff0c\u6709\u8fd9\u4e48\u9ad8\u4fdd\u62a4\u7387\u7684\u539f\u56e0\u3002\u6211\u7406\u89e3\uff0c\u5927\u4f17\u5bf9mRNA\u7684\u957f\u671f\u5b89\u5168\u6027\u6709\u987e\u8651\u3002\u4f46\u662f\uff0c\u75ab\u82d7\u63a5\u79cd\u53f2\u544a\u8bc9\u6211\u4eec\uff0c\u75ab\u82d7\u7684\u526f\u4f5c\u7528\uff0c\u81f3\u5c1190%\u4ee5\u4e0a\uff0c\u901a\u5e38\u53d1\u751f\u5728\u75ab\u82d7\u63a5\u79cd\u540e2\u4e2a\u6708\u3002\u8fd9\u662f\u4e3a\u4ec0\u4e48FDA\u4e0d\u6388\u6743\u7d27\u6025\u4f7f\u7528\uff0c\u9664\u975e\u6709\u4e00\u534aIII\u671f\u4e34\u5e8a\u53c2\u4e0e\u8005\u63a5\u53d7\u7b2c\u4e8c\u9488\u75ab\u82d7\u540e\u957f\u8fbe\u4e24\u4e2a\u6708\u7684\u5b89\u5168\u6027\u6570\u636e\u3002\u5bf9\u4e09\u6708\u4efd\u63a5\u79cd\u7b2c\u4e8c\u5242\u75ab\u82d7\u7684\u53c2\u4e0e\u8005\uff0c\u6211\u4eec\u6bcf\u4e2a\u6708\u8ffd\u8e2a\u4ed6\u4eec\u7684\u5b89\u5168\u6027\u6570\u636e\uff0c\u81f3\u4eca\u6ca1\u6709\u53d1\u73b0\u4efb\u4f55\u5b89\u5168\u95ee\u9898\u3002\u5bf9\u5927\u5bb6\u5173\u5fc3\u7684\u957f\u671f\u5b89\u5168\u6027\u95ee\u9898\uff0c\u5982\u751f\u80b2\u7b49\u7b49\uff0c\u53c2\u52a0III\u671f\u4e34\u5e8a\u8005\u4e2d\u6709\u5b55\u5987\uff0c\u63a5\u79cd\u75ab\u82d7\u540e\u8fd8\u751f\u4e0b\u4e86\u5b69\u5b50\u3002\u6240\u4ee5\uff0c\u6211\u4eec\u5bf9COVID-19 mRNA\u75ab\u82d7\u7684\u77ed\u671f\u4e0e\u957f\u671f\u5b89\u5168\u6027\u90fd\u975e\u5e38\u6709\u4fe1\u5fc3\u3002<br>\u4e3b\u6301\u4eba\uff1a\u8c22\u8c22\u3002\u663e\u7136\uff0cmRNA\u5e73\u53f0\u548cSARS-CoV-2 S-2P\u5bf9COVID-19 mRNA\u75ab\u82d7\u7684\u6210\u529f\u53d1\u6325\u4e86\u5173\u952e\u4f5c\u7528\u3002\u90a3\u600e\u4e48\u73b0\u5728\u90a3\u4e48\u591a\u516c\u53f8\u90fd\u4f7f\u7528SARS-CoV-2 S-2P\u6765\u7814\u53d1\u65b0\u51a0\u75ab\u82d7\u5462\uff1f\u8c01\u5728\u63a8\u52a8\u8fd9\u4e9b\u4fe1\u606f\u5171\u4eab\uff1f<br>Corbett\uff1a\u6211\u60f3\uff0cBarney Graham\u535a\u58eb\u53ef\u80fd\u5728\u5a92\u4f53\u4e0a\u8bf4\u4e86\u3002\u4ed6\u76f4\u63a5\u7ed9Pfizer CEO\u6253\u7535\u8bdd\uff0c\u544a\u8bc9\u4ed6\u4eec\u7528SARS-CoV-2 S-2P\u3002\u8fd9\u662fPfizer\u83b7\u5f97\u8fd9\u4e2a\u4fe1\u606f\u7684\u65b9\u5f0f\u3002\u8bb8\u591a\u5176\u5b83\u516c\u53f8\u5c1d\u8bd5\u4e86\u5176\u5b83\u51e0\u4e4e\u6240\u6709\u53ef\u80fd\u7684\u65b9\u5f0f\u3002Johnson &amp; Johnson\u53d1\u8868\u4e86\u597d\u51e0\u79cd\u5019\u9009\u75ab\u82d7\u3002\u4ed6\u4eec\u5c1d\u8bd5\u4e0d\u4f7f\u7528S-2P\uff0c\u4ed6\u4eec\u8bd5\u4e86\u91ce\u751f\u578b\u68d8\u7a81\u86cb\u767d\uff0c\u8bd5\u4e86RBD (\u53d7\u4f53\u7ed3\u5408\u7ed3\u6784\u57df)\u3002\u4f46\u662f\u8fd8\u662fS-2P\u80dc\u51fa\u3002\u54c8\u4f5b\u7684Dan Barouch\u505a\u7684Johnson &amp; Johnson \u7684\u7334\u5b50\u8bd5\u9a8c\uff0c\u8c08\u5230\u514d\u75ab\u53cd\u5e94\uff0cS-2P\u8fd8\u662f\u4e00\u76f4\u5f3a\u4e8e\u4ed6\u4eec\u7684\u5176\u5b83\u5019\u9009\u75ab\u82d7\u3002\u6211\u4eec\u7684\u67091000\u591a\u500d\u7684\u4e2d\u548c\u6ef4\u5ea6\u3002\u6211\u8ba4\u4e3a\uff0c\u4f60\u5982\u679c\u662f\u516c\u53f8\uff0c\u4f60\u4f1a\u6839\u636e\u6570\u636e\u505a\u51fa\u9009\u62e9\u3002AstraZeneca \u6ca1\u6709\u7528S-2P\u3002\u5f53\u4ed6\u4eec\u7684\u6570\u636e\u51fa\u6765\u7684\u65f6\u5019\uff0c\u55ef\u2026\u2026\uff0c 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\u00b5g\u3002\u6211\u4eec\u6700\u8fd1\u521a\u5728BioRxiv\u4e0a\u53d1\u4e86\u4e00\u7bc7\u6587\u7ae0\uff0c 30 \u00b5g \u548c100 \u00b5g\u3002\u4f60\u53ef\u4ee5\u770b\u5230\uff0c\u5373\u4fbf\u662f\u5728\u7334\u5b50\u8eab\u4e0a\uff0c30 \u00b5g\u8bf1\u5bfc\u7684\u4e2d\u548c\u6297\u4f53\u6ef4\u5ea6\u4e5f\u662f\u6709\u9ad8\u6709\u4f4e\u3002<br>\u4e3b\u6301\u4eba\uff1a\u65e2\u7136\u6211\u4eec\u8c08\u5230\u5242\u91cf\uff0cPfizer\u91c7\u752830 \u00b5g, Moderna\u91c7\u7528100 \u00b5g\uff0c\u90a3\u4e48\u5728\u4ec0\u4e48\u8303\u56f4\u53ef\u83b7\u5f97\u6700\u5927\u9650\u5ea6\u7684\u4fdd\u62a4\u7387\uff0c\u4f46\u5f15\u8d77\u66f4\u5c0f\u7684\u526f\u4f5c\u7528\uff1f<br>Corbett\uff1aPfizer \u75ab\u82d7\u7684\u526f\u4f5c\u7528\u5e76\u4e0d\u6bd4Moderna\u7684\u5c11\u3002\u526f\u4f5c\u7528\u7684\u90e8\u5206\u539f\u56e0\uff0c\u4ed6\u4eec\u7684mRNA\u5e73\u53f0\u53ea\u662f\u5728\u5236\u5242\u914d\u65b9\u4e0a\u6709\u7ec6\u5fae\u5dee\u522b\u3002\u4f46\u662f\uff0cPfizer\u548cModerna\u7684\u75ab\u82d7\u90fd\u6709\u540c\u6837\u7684\u526f\u4f5c\u7528\uff0c\u65e0\u8bba\u5242\u91cf\u591a\u5c11\u3002\u5728I\u671f\u4e34\u5e8a\uff0c\u6211\u4eec\u6d4b\u8bd5\u4e8625 \u00b5g, 100 \u00b5g \u548c250 \u00b5g\u3002\u6211\u4eec\u9009\u4e86100 \u00b5g\u3002\u5728II\u671f\u4e34\u5e8a\uff0c\u6211\u4eec\u8fd8\u6d4b\u8bd5\u4e8650 \u00b5g\u3002\u4f60\u4eec\u4eceModerna CEO\u90a3\u542c\u8bf450 \u00b5g\u7684\u6570\u636e\u5f88\u68d2\u300250 \u00b5g\u7684\u6570\u636e\u786e\u5b9e\u5f88\u68d2\u3002\u4f46\u662f\u7531\u4e8e\u6bcf\u4e00\u6b65\u90fd\u8d70\u5f97\u5f88\u5feb\uff0c\u6bcf\u4e00\u4e2a\u8282\u70b9\uff0c\u5f53FDA\u544a\u8bc9\u53ef\u4ee5\u8fdb\u884c\u4e0b\u4e00\u6b65\u65f6\uff0c\u6211\u4eec\u5c31\u6839\u636e\u6211\u4eec\u6240\u5f97\u5230\u7684\u6700\u6709\u5e0c\u671b\u7684\u6570\u636e\u505a\u51fa\u51b3\u5b9a\u30022020\u5e747\u6708\u4e2d\u4e0b\u65ec\uff0cFDA\u544a\u8bc9\u6211\u4eec\u53ef\u4ee5\u8fdb\u884cIII\u671f\u4e34\u5e8a\u4e86\uff0c\u8bf4\uff1a\u201c\u4f60\u4eec\u7684\u5b89\u5168\u6027\u6570\u636e\u5f88\u68d2\uff0c\u514d\u75ab\u53cd\u5e94\u5f88\u68d2\u7b49\u7b49\u201d\u3002\u6211\u4eec\u5c31\u9009\u62e9100 \u00b5g\u8fdb\u884cIII\u671f\u4e34\u5e8a\u4e86\uff0c\u56e0\u4e3a100 \u00b5g\u7684\u6570\u636e\u662f\u6211\u4eec\u5f97\u5230\u7684\u6700\u6709\u5e0c\u671b\u7684\u6570\u636e\uff0c 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Johnson\u548cNovavax\u5728\u8fd9\u4e9b\u53d8\u5f02\u682a\u6d41\u884c\u7684\u5730\u65b9\u8fdb\u884c\u4e86III\u671f\u4e34\u5e8a\uff0c\u6709\u4e00\u4e9b\u6548\u679c\u3002\u6211\u4eec\u5bf9Moderna\u75ab\u82d7\u505a\u4e86\u6d4b\u8bd5\uff0cModerna\u75ab\u82d7\u5bf9\u8fd9\u4e9b\u53d8\u5f02\u682a\u7684\u6548\u679c\u964d\u4f4e\u4e86\u4e00\u4e9b\uff0c\u7ed3\u679c\u4eca\u5929\u521a\u516c\u5e03\u5728BioRxiv\u4e0a\u3002\u662f\u7684\uff0c\u662f\u6709\u4e9b\u964d\u4f4e\u3002\u4f46\u4ece\u5168\u7403\u6765\u8bf4\uff0c\u4f4e\u5230\u8ba9\u6211\u4eec\u89c9\u5f97\u6211\u4eec\u5f97\u5c3d\u5feb\u8ba9\u6c11\u4f17\u63a5\u79cd\u75ab\u82d7\uff0c\u963b\u6b62\u53d8\u5f02\u682a\u7684\u4f20\u64ad\u3002\u4e8b\u5b9e\u4e0a\uff0c\u8bb8\u591a\u516c\u53f8\u5df2\u7ecf\u5f00\u59cb\u7814\u5236\u9488\u5bf9\u5357\u975e\u53d8\u5f02\u682a\u7684\u75ab\u82d7\uff0c\u5305\u62ecModerna\uff0c\u8fd9\u662f\u76ee\u524d\u552f\u4e00\u4e00\u4e2a\u53d8\u5f02\u682a\u663e\u793a\u76ee\u524d\u7684\u75ab\u82d7\u6548\u679c\u51cf\u5f31\u4e86\u3002\u603b\u4e4b\uff0c\u6211\u4eec\u5f97\u5c3d\u5feb\u8ba9\u5927\u5bb6\u6253\u75ab\u82d7\uff0c\u8fd9\u6837\u6211\u4eec\u624d\u80fd\u963b\u65ad\u75c5\u6bd2\u4f20\u64ad\u3002\u8fd8\u6709\u4e00\u4ef6\u4e8b\u6211\u60f3\u5f3a\u8c03\uff0c\u4e0d\u7ba1\u65b0\u51a0\u75c5\u6bd2\u5982\u4f55\u53d8\u5f02\uff0c\u6211\u4eec\u6700\u5f00\u59cb\u5f3a\u8c03\u76843Ws (Wear a mask, wash hands, watch distance from others) \u90fd\u662f\u5728\u75ab\u82d7\u666e\u53ca\u4e4b\u524d\u6700\u6709\u6548\u7684\u9632\u62a4\u63aa\u65bd\uff0c\u800c\u4e14\u662f\u5bf9\u4efb\u4f55\u4e00\u79cd\u611f\u67d3\u547c\u5438\u9053\u7684\u75c5\u6bd2\u90fd\u8f83\u4e3a\u6709\u6548\u7684\u9632\u62a4\u63aa\u65bd\u3002<br>\u4e3b\u6301\u4eba: \u4e00\u4f4d\u540d\u53ebEdward\u7684\u89c2\u4f17\u63d0\u95ee\uff1a\u6211\u4eec\u53ef\u4ee5\u4e24\u9488\u6253\u4e0d\u540c\u516c\u53f8\u7684\u75ab\u82d7\u5417\uff1f<br>Corbett\uff1a\u6211\u77e5\u9053\uff0c\u5927\u5bb6\u4ece\u6709\u4e9b\u5dde\u653f\u5e9c\u5904\u542c\u8bf4\u53ef\u4ee5\u4e00\u9488\u6253Pfizer\u7684\u75ab\u82d7\uff0c\u53e6\u4e00\u9488\u6253Moderna\u7684\u75ab\u82d7\uff0c\u53cd\u4e4b\u4ea6\u7136\u3002\u5982\u679c\u4f60\u662f\u4e00\u4e2a\u75ab\u82d7\u5b66\u5bb6\uff0c\u4f60\u4e5f\u77e5\u9053\uff0c\u5934\u9488\u6253DNA\uff0c\u52a0\u5f3a\u9488\u6253\u86cb\u767d\u6216\u5176\u4ed6\u5f62\u5f0f\u7684\u75ab\u82d7\u53ef\u4ee5\u8bf1\u5bfc\u66f4\u5f3a\u7684\u514d\u75ab\u53cd\u5e94\u3002\u4f46\u73b0\u9636\u6bb5\uff0c\u5927\u5bb6\u4e24\u9488\u8fd8\u662f\u4f1a\u5f97\u5230\u540c\u4e00\u4e2a\u516c\u53f8\u7684\u75ab\u82d7\u3002\u5982\u679c\u4f60\u9009\u62e9Johnson &amp; Johnson\uff0c\u4f60\u53ea\u6253\u4e00\u9488\u3002\u5f53\u7136\uff0cJohnson &amp; Johnson \u8fd8\u5728\u8fdb\u884c\u4e24\u9488\u7ed9\u836f\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<br>\u4e3b\u6301\u4eba\uff1a\u6709\u89c2\u4f17\u95ee\uff0c\u4f60\u89c9\u5f97\u4ee5\u540e\u6211\u4eec\u6bcf\u5e74\u90fd\u9700\u8981\u6253\u65b0\u51a0\u75ab\u82d7\u5417\uff1f<br>Corbett\uff1a\u6211\u4e0d\u80fd\u505a\u51fa\u8fd9\u6837\u7684\u63a8\u6d4b\u3002\u75c5\u6bd2\u4e00\u76f4\u5728\u53d8\u5f02\u3002\u6211\u7684\u63a8\u6d4b\u662f\u7b49\u5230\u75c5\u6bd2\u9700\u8981\u6211\u4eec\u66f4\u65b0\u75ab\u82d7\u7684\u65f6\u5019\u3002<br>\u5468\u521a ( \u672c\u6b21\u6d3b\u52a8\u6280\u672f\u652f\u6301)\uff1a\u505a\u65b0\u75ab\u82d7\u8981\u591a\u4e45\uff1f<br>Corbett\uff1aModerna\u5df2\u7ecf\u5f00\u59cb\u4e86\u3002\u4ed6\u4eec\u5185\u90e8\u76ee\u6807\u662f30\u5929\u3002\u8fd9\u662fmRNA\u75ab\u82d7\u7684\u597d\u5904!<br>Q&amp;A\u4e4b\u540e\uff0c\u5927\u4e13\u8054\u4f1a\u957f\u674e\u6c11\u535a\u58eb\u4ee3\u8868\u5927\u4e13\u8054\u3001\u53c2\u4e0e\u8bb2\u5ea7\u7684\u89c2\u4f17\u548c\u534e\u88d4\u793e\u533a\uff0c\u81f4\u8f9e\u611f\u8c22\u6f14\u8bb2\u5609\u5bbeCorbett\u535a\u58eb\u7684\u7cbe\u5f69\u5206\u4eab\u548c\u89e3\u7b54\uff0c\u540c\u65f6\u611f\u8c22\u53c2\u4e0e\u7ec4\u7ec7\u8bb2\u5ea7\u7684\u5404\u4f4d\u5fd7\u613f\u8005\u548c\u5404\u4f4d\u89c2\u4f17\u7684\u652f\u6301\u3002<br>\u75ab\u82d7\u8bb2\u5ea7\u4e4b\u540e\uff0c\u7531\u4e2d\u79d1\u9662\u4e0a\u6d77\u751f\u5316\u7ec6\u80de\u7814\u7a76\u6240\u6d77\u5916\u8054\u8c0a\u4f1a\u7684\u516d\u4f4d\u6821\u53cb\u5171\u540c\u62c5\u7eb2\uff0c\u7ec4\u7ec7\u4e86\u6709\u5173\u65b0\u51a0\u75ab\u82d7\u7684\u8ba8\u8bba\u4f1a\u3002NIAID\u8bfe\u9898\u7ec4\u957f\u6731\u9526\u82b3\u535a\u58eb\u4e3b\u6301\u4e86\u8ba8\u8bba\u4f1a\uff0cCerevel Therapeutics\u516c\u53f8\u9ad8\u7ea7\u603b\u76d1\u7684\u738b\u5e7f\u826f\u535a\u58eb\u3001GlycoT Theraputics\uff0cLLC \u516c\u53f8\u5408\u4f19\u4eba\u53ca\u7814\u53d1\u603b\u76d1\u7684\u6768\u5f3a\u535a\u58eb\u4ee5\u53ca\u6c88\u5fd7\u6c11\u3001\u5218\u7fe0\u5e73\u7b49\u51e0\u4f4d\u6821\u53cb\u53c2\u4e0e\u8ba8\u8bba\u3002\u8ba8\u8bba\u4f1a\u9488\u5bf9\u65b0\u51a0\u5bf9\u4e0d\u540c\u5e74\u9f84\u6bb5\u4eba\u7fa4\u7684\u5f71\u54cd\u3001\u5168\u7403\u6b63\u5728\u7814\u53d1\u6216\u65bd\u6253\u7684\u65b0\u51a0\u75ab\u82d7\u7684\u7c7b\u578b\u3001\u5b89\u5168\u6027\u3001\u526f\u4f5c\u7528\u3001\u6709\u6548\u6027\u7b49\u95ee\u9898\u8fdb\u884c\u4e86\u6df1\u5165\u63a2\u8ba8\u548c\u7b54\u7591\u3002\u6768\u5f3a\u535a\u58eb\u4f5c\u4e3a\u8f89\u745e (Pfizer) mRNA \u75ab\u82d7III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5fd7\u613f\u8005\uff0c\u8fd8\u5206\u4eab\u4e86\u4e2a\u4eba\u65bd\u6253\u75ab\u82d7\u540e\u7684\u7ecf\u5386\u548c\u526f\u4f5c\u7528\u3002\u8ba8\u8bba\u4f1a\u8fd8\u5411\u534e\u4eba\u793e\u533a\u63d0\u4f9b\u4e86\u8ffd\u6eaf\u75ab\u60c5\u3001\u9884\u5148\u767b\u8bb0\u65bd\u6253\u75ab\u82d7\u7f51\u7ad9\u7b49\u4fe1\u606f\u3002\u89c2\u4f17\u670b\u53cb\u4eec\u70ed\u70c8\u54cd\u5e94\uff0c\u73b0\u573a\u63d0\u51fa\u4e86\u5927\u91cf\u95ee\u9898\uff0c\u8bb8\u591a\u4eba\u8fd8\u5728ZOOM\u7684chat\u91cc\u79ef\u6781\u53c2\u4e0e\u8ba8\u8bba\u3002<br><img data-recalc-dims=\"1\" decoding=\"async\"   src=\"https:\/\/i0.wp.com\/caagw.org\/sites\/default\/files\/images\/caagw_2.8_4.png?w=640&#038;ssl=1\"><br>\u8ba8\u8bba\u4f1a\u6700\u540e\uff0c\u4e2d\u79d1\u9662\u4e0a\u6d77\u751f\u5316\u7ec6\u80de\u7814\u7a76\u6240\u6d77\u5916\u8054\u8c0a\u4f1a\u4f1a\u957f\u5b59\u900a\u535a\u58eb\u81f4\u8f9e\u611f\u8c22\u53c2\u4e0e\u8ba8\u8bba\u4f1a\u7684\u5404\u4f4d\u6821\u53cb\u548c\u89c2\u4f17\u3002<br>\u201cFeatured Seminar and Discussion on COVID-19 Vaccines\u201d 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